Development of control serum for microbial antibody tests

Biologicals. 2001 Mar;29(1):39-43. doi: 10.1006/biol.2001.0274.

Abstract

Control sera are an essential component of in-vitro clinical diagnostic reagents. We have developed a control serum for HBsAg, anti-HCV, anti-HIV and anti- Treponema pallidum testing. Since this control serum is prepared from human plasma, we paid special attention to viral safety. We incorporated three viral inactivation methods into the manufacturing process that maintain the necessary characteristics of a stable control serum.

MeSH terms

  • Antibodies, Bacterial / blood
  • Enzyme-Linked Immunosorbent Assay
  • HIV / immunology
  • HIV / isolation & purification*
  • HIV Antibodies / blood
  • Hepacivirus / immunology
  • Hepacivirus / isolation & purification*
  • Hepatitis B Antibodies / blood
  • Hepatitis B virus / immunology
  • Hepatitis B virus / isolation & purification*
  • Humans
  • Immune Sera*
  • Treponema pallidum / immunology
  • Treponema pallidum / isolation & purification*

Substances

  • Antibodies, Bacterial
  • HIV Antibodies
  • Hepatitis B Antibodies
  • Immune Sera