Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters. Commentary re: P. Münster et al., Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. Clin. Cancer Res., 7: 2228-2236, 2001

Clin Cancer Res. 2001 Aug;7(8):2155-8.

Author

E A Sausville¹

Affiliation

¹ Developmental Therapeutics Program, National Cancer Institute, 6130 Executive Boulevard, Rockville, MD 20852, USA. [email protected]

PMID: 11489788

No abstract available

Publication types

Comment

MeSH terms

Anti-Bacterial Agents / pharmacology*
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects
Benzoquinones
Breast Neoplasms / drug therapy
Breast Neoplasms / pathology
Breast Neoplasms / physiopathology
Drug Synergism
HSP90 Heat-Shock Proteins / drug effects
HSP90 Heat-Shock Proteins / physiology
Humans
Lactams, Macrocyclic
Retinoblastoma Protein / drug effects
Retinoblastoma Protein / physiology
Rifabutin / analogs & derivatives
Rifabutin / pharmacology
Tumor Cells, Cultured / drug effects

Substances

Anti-Bacterial Agents
Antineoplastic Agents, Phytogenic
Benzoquinones
HSP90 Heat-Shock Proteins
Lactams, Macrocyclic
Retinoblastoma Protein
Rifabutin
tanespimycin