The first potent and selective inhibitors of the glycine transporter type 2

J Med Chem. 2001 Aug 16;44(17):2679-82. doi: 10.1021/jm0011272.

Authors

W L Caulfield¹, I T Collie, R S Dickins, O Epemolu, R McGuire, D R Hill, G McVey, J R Morphy, Z Rankovic, H Sundaram

Affiliation

¹ Lead Discovery Unit, Organon Laboratories Ltd., Newhouse ML1 5SH, Scotland, UK.

PMID: 11495577
DOI: 10.1021/jm0011272

No abstract available

MeSH terms

Amino Acid Transport Systems, Neutral*
Animals
Benzamides / chemical synthesis*
Benzamides / chemistry
Benzamides / metabolism
Benzamides / pharmacology
Carrier Proteins / antagonists & inhibitors*
Combinatorial Chemistry Techniques
Glycine / metabolism*
Glycine Plasma Membrane Transport Proteins
Humans
In Vitro Techniques
Mice
Microsomes, Liver / metabolism
Structure-Activity Relationship

Substances

4-benzyloxy-3,5-dimethoxy-N-((1-dimethylaminocyclopentyl)methyl)benzamide
Amino Acid Transport Systems, Neutral
Benzamides
Carrier Proteins
Glycine Plasma Membrane Transport Proteins
Glycine