Beneficial effect of intravenous lidocaine in cutaneous chronic graft-versus-host disease secondary to donor lymphocyte infusion

J C Voltarelli; H Ahmed; E J Paton; A B Stracieri; P Holman; A Bashey; M Coutinho; B P Simoes; E D Ball; E Carrier

doi:10.1038/sj.bmt.1703080

Beneficial effect of intravenous lidocaine in cutaneous chronic graft-versus-host disease secondary to donor lymphocyte infusion

Bone Marrow Transplant. 2001 Jul;28(1):97-9. doi: 10.1038/sj.bmt.1703080.

Authors

J C Voltarelli¹, H Ahmed, E J Paton, A B Stracieri, P Holman, A Bashey, M Coutinho, B P Simoes, E D Ball, E Carrier

Affiliation

¹ Bone Marrow Transplantation Unit, University Hospital, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.

PMID: 11498752
DOI: 10.1038/sj.bmt.1703080

Abstract

We report two cases of refractory chronic graft-versus-host disease after donor lymphocyte infusions in which the skin lesions improved dramatically with the use of intravenous pulses of lidocaine. This form of therapy has been used successfully for the cutaneous involvement of scleroderma and may have vasodilator and anti-inflammatory effects.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Bone Marrow Transplantation
Child
Chronic Disease
Female
Graft vs Host Disease / drug therapy
Graft vs Host Disease / etiology
Graft vs Host Disease / pathology*
Humans
Injections, Intravenous
Leukemia / complications
Leukemia / therapy
Lidocaine / administration & dosage*
Lymphocyte Transfusion / adverse effects*
Male
Recurrence
Scleroderma, Localized / drug therapy
Scleroderma, Localized / etiology
Scleroderma, Localized / pathology
Skin Diseases / drug therapy*
Skin Diseases / etiology
Skin Diseases / pathology
Transplantation, Homologous

Substances

Lidocaine