Abstract
In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.
MeSH terms
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Animals
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Enterotoxins / administration & dosage*
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Enterotoxins / immunology*
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Interleukin-12 / metabolism*
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Interleukin-18 / metabolism
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Mice
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Spleen / immunology
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Staphylococcus aureus / metabolism*
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Superantigens / administration & dosage
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Superantigens / immunology
Substances
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Enterotoxins
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Interleukin-18
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Superantigens
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Interleukin-12
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enterotoxin B, staphylococcal