Combination of renal agenesis with respiratory and alimentary tract atresia results in normal lung development

Am J Med Genet. 2001 Sep 1;102(4):327-9. doi: 10.1002/ajmg.1485.

Abstract

The VACTERL complex comprises renal agenesis and atresias of the alimentary and respiratory tracts. We report on a case with this combination causing severe oligohydramnios but with normal lung development. The likely protective mechanism for pulmonary development was an increase in alveolar pressure and reduced alveolar fluid loss due to the esophageal-tracheal malformation. This suggests the possible treatment of oligohydramnios by tracheal occlusion.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / physiopathology
  • Duodenal Obstruction / congenital*
  • Duodenal Obstruction / physiopathology
  • Esophageal Atresia / physiopathology
  • Euthanasia, Passive
  • Female
  • Humans
  • Infant, Newborn
  • Intestinal Atresia / physiopathology*
  • Kidney / abnormalities*
  • Kidney / physiopathology
  • Lung / growth & development*
  • Male
  • Pregnancy
  • Respiratory System Abnormalities / physiopathology*