Synthesis and biological evaluation of methoxyphenyl porphyrin derivatives as potential photodynamic agents

M E Milanesio; F S Morán; E I Yslas; M G Alvarez; V Rivarola; E N Durantini

doi:10.1016/s0968-0896(01)00138-9

Synthesis and biological evaluation of methoxyphenyl porphyrin derivatives as potential photodynamic agents

Bioorg Med Chem. 2001 Aug;9(8):1943-9. doi: 10.1016/s0968-0896(01)00138-9.

Authors

M E Milanesio¹, F S Morán, E I Yslas, M G Alvarez, V Rivarola, E N Durantini

Affiliation

¹ Departamento de Química y Física, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, 5800, Río Cuarto, Argentina.

PMID: 11504630
DOI: 10.1016/s0968-0896(01)00138-9

Abstract

A new meso-2,4,6-trimethoxyphenyl porphyrin covalently linked to a 2',6'-dinitro-4'-trifluoromethylphenyl group by an amine bond 5 and its metal complex with Cd(II) 6 was prepared. The photodynamic activities of 5 and 6 were evaluated in vitro on Hep-2 cells. A considerable increase in the photocytotoxic effect was found for 6, which has higher singlet molecular oxygen, O(2)((1)Delta(g)), production.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Oxygen / analysis
Oxygen / chemistry
Photosensitizing Agents / chemical synthesis*
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology
Porphyrins / chemical synthesis
Porphyrins / chemistry
Porphyrins / pharmacology
Tumor Cells, Cultured

Substances

Photosensitizing Agents
Porphyrins
methoxyphenyl porphyrin
Oxygen