Abstract
A series of 3,4-dihydro-1H-1,4-oxazino[4,3-a]indoles bearing basic side chains has been synthesized by a novel chemical process. These compounds have been screened for potential antidepressant activity. One of these derivatives, 3,4-dihydro-1,10-dimethyl-1-(3-methylaminopropyl)-1H-1,4-oxazino[4,3-a]indole (AY-23,673), was particularly potent in the prevention of reserpine ptosis test in mice, with an ED50 of 0.5 mg/kg ip.
MeSH terms
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Animals
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Antidepressive Agents / chemical synthesis*
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Antidepressive Agents / pharmacology
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Antidepressive Agents / toxicity
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Blepharoptosis / prevention & control
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Indoles / chemical synthesis*
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Indoles / pharmacology
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Indoles / toxicity
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Lethal Dose 50
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Mice
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Oxazines / chemical synthesis
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Oxazines / pharmacology
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Oxazines / toxicity
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Reserpine / antagonists & inhibitors
Substances
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Antidepressive Agents
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Indoles
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Oxazines
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Reserpine