Systemic lupus erythematosus and thrombotic thrombocytopenic purpura: a case and review

Pediatr Nephrol. 2001 Aug;16(8):672-4. doi: 10.1007/s004670100625.

Abstract

Thrombotic thrombocytopenic purpura (TTP) is rare in children with systemic lupus erythematosus (SLE). We report a 15-year-old female who simultaneously presented with TTP and SLE. Kidney biopsy showed membranous nephropathy. Her condition improved with plasmapheresis, intravenous cyclophosphamide, and prednisone pulse therapy. We also reviewed the literature for this association in pediatric patients comparing presenting sequence and renal pathology with cases documented in the adult literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Cyclophosphamide / therapeutic use
  • Female
  • Glomerulonephritis, Membranous / complications
  • Glomerulonephritis, Membranous / pathology
  • Glomerulonephritis, Membranous / therapy
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Injections, Intravenous
  • Kidney / pathology
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / therapy
  • Plasmapheresis
  • Prednisone / therapeutic use
  • Purpura, Thrombotic Thrombocytopenic / complications*
  • Purpura, Thrombotic Thrombocytopenic / therapy

Substances

  • Glucocorticoids
  • Immunosuppressive Agents
  • Cyclophosphamide
  • Prednisone