Abstract
Two new cholestane bisdesmosides (1, 2) based upon (22S)-cholest-5-ene-3 beta,16 beta,22-triol with an acetyl group at the sugar moiety and three new ones (3-5) based upon (22S)-cholest-5-ene-1 beta,3 beta,16 beta,22-tetrol, along with a known cholestane glycoside, were isolated from the bulbs of Galtonia candicans. The structures of the new compounds were determined by spectroscopic analysis and chemical transformations.
MeSH terms
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Cholestanes / chemistry
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Cholestanes / isolation & purification*
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Cholestanes / pharmacology
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Chromatography, High Pressure Liquid
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Dose-Response Relationship, Drug
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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HL-60 Cells / drug effects
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Humans
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Japan
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Liliaceae / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plants, Medicinal / chemistry*
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Tumor Cells, Cultured / drug effects