The aim of this study is the analysis of medical selection of drivers and candidates for car drivers. The examination included 41,561 drivers (36,008 candidates for car drivers sent to preliminary medical examination, 5,175 professional drivers sent to periodic medical examination and 378 drivers sent to special medical examination). At the preliminary medical examination, 1.5% of candidates for car drivers were declared to be incapable of driving and 8.4% of candidates had a limited driving ability. At the periodic medical examination, 8.2% of drivers were declared to be incapable to driving and 26% of drivers had a limited driving ability. At the special medical examination, 34.9% of drivers were declared to be incapable for driving and 54.3% of drivers had a limited driving ability. The reasons for driving incapability and for limited driving ability were the disturbances of psychologic-psychiatric and neurologic state, cardiovascular diseases, endocrine diseases and sight disturbances. In our opinion, medical selection of drivers and candidates for car drivers is a significant preventive measure of traffic trauma. New, more subtle methods for determination of the latent disturbances must be developed. Periodic medical examination for amateurs in the period between the preliminary medical examination and 65 years of age must biobligatory.