Abstract
This is a review of the data available in the literature and the authors' own findings on pathogenetical rationale for the use and clinical study of current treatments for Alzheimer's disease (AD) (synonym: Alzheimer-type dementia). In the past decade many attempts have been made at targeting different links of the pathogenesis of a neurodegenerative process that underlie AD. Several areas of pathogenetical therapy for AD have been developed on the basis of experimental studies and pilot clinical tests. The most developed areas are as follows: various compensatory (replacement) treatments aimed at overcoming neurotransmitter deficit in different neuronal systems that are damaged in AD to a greater or lesser extent; neuroprotective therapy promoting increased viability (survival) of neurons and their plasticity, and vasoactive therapy. Rather new directions of AD pathogenetic therapy, such as antiinflammatory and hormonal therapy along with antiamyloid therapeutic strategies are still under study.
MeSH terms
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Aged
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Alzheimer Disease / drug therapy*
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Alzheimer Disease / etiology
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Alzheimer Disease / physiopathology
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Amino Acids / administration & dosage
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Amino Acids / therapeutic use
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Aminoquinolines*
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Carbamates / administration & dosage
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Carbamates / therapeutic use
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Cholinesterase Inhibitors / administration & dosage
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Cholinesterase Inhibitors / therapeutic use
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Clinical Trials as Topic
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Donepezil
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Dopamine Agents / administration & dosage
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Dopamine Agents / therapeutic use
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Estrogens / therapeutic use
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Ginkgo biloba
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Humans
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Indans / administration & dosage
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Indans / therapeutic use
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Memantine / administration & dosage
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Memantine / therapeutic use
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Monoamine Oxidase Inhibitors / administration & dosage
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Monoamine Oxidase Inhibitors / therapeutic use
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Multicenter Studies as Topic
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Neuronal Plasticity
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Neuroprotective Agents / administration & dosage
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Neuroprotective Agents / therapeutic use
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Neurotransmitter Agents / physiology
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Nicergoline / administration & dosage
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Nicergoline / therapeutic use
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Nootropic Agents / administration & dosage
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Nootropic Agents / therapeutic use
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Phenylcarbamates*
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Phytotherapy
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Piperidines / administration & dosage
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Piperidines / therapeutic use
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Piracetam / administration & dosage
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Piracetam / therapeutic use
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Pyrithioxin / administration & dosage
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Pyrithioxin / therapeutic use
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Rivastigmine
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Selegiline / administration & dosage
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Selegiline / therapeutic use
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Tacrine / administration & dosage
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Tacrine / therapeutic use
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Time Factors
Substances
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Amino Acids
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Aminoquinolines
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Carbamates
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Cholinesterase Inhibitors
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Dopamine Agents
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Estrogens
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Indans
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Monoamine Oxidase Inhibitors
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Neuroprotective Agents
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Neurotransmitter Agents
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Nootropic Agents
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Phenylcarbamates
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Piperidines
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Selegiline
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cerebrolysin
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Tacrine
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Donepezil
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Pyrithioxin
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amiridine
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Nicergoline
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Rivastigmine
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Memantine
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Piracetam