Abstract
The authors report a patient with chorea and multifocal neurologic abnormalities associated with a small-cell lung carcinoma. A previously unreported antibody directed at a 76-kD neuronal protein antigen was identified in both serum and CSF. Antitumor treatment resulted in dramatic and sustained clinical neurologic and serologic responses.
MeSH terms
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Animals
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Carcinoma, Small Cell / blood
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Carcinoma, Small Cell / cerebrospinal fluid
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Carcinoma, Small Cell / therapy*
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Chorea / blood
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Chorea / cerebrospinal fluid
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Chorea / therapy*
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Female
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Humans
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Lung Neoplasms / blood
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Lung Neoplasms / cerebrospinal fluid
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Lung Neoplasms / therapy*
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Magnetic Resonance Imaging
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Middle Aged
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Paraneoplastic Syndromes / blood
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Paraneoplastic Syndromes / cerebrospinal fluid
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Paraneoplastic Syndromes / therapy*
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Rats