High-dose omeprazole in esophagitis with stenosis after surgical treatment of esophageal atresia

J Pediatr Surg. 2001 Sep;36(9):1416-8. doi: 10.1053/jpsu.2001.26388.

Abstract

The authors describe 4 children with recurrent stenosis and persistent esophagitis after secondary repair of a long gap esophageal atresia. They underwent an esophageal reconstruction by elongation of the lesser gastric curvature according to Schärli at the age of 11 to 14 months. All had esophagitis grade III to IV (Savary-Miller classification), esophageal stenosis, and failure to thrive. Effective treatment of the esophagitis and prevention of stenosis consisted in high doses of omeprazole (1.9 to 2.5 mg/kg/d). After this treatment, the need for esophageal dilatation disappeared, and nutritional status normalized.

Publication types

  • Case Reports

MeSH terms

  • Digestive System Surgical Procedures / adverse effects*
  • Digestive System Surgical Procedures / methods
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / administration & dosage
  • Esophageal Atresia / diagnosis
  • Esophageal Atresia / surgery*
  • Esophageal Stenosis / drug therapy*
  • Esophageal Stenosis / etiology
  • Esophagitis / drug therapy*
  • Esophagitis / etiology
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Male
  • Omeprazole / administration & dosage*
  • Plastic Surgery Procedures / adverse effects
  • Plastic Surgery Procedures / methods
  • Postoperative Complications / drug therapy
  • Treatment Outcome

Substances

  • Enzyme Inhibitors
  • Omeprazole