A streamlined synthesis for 2,3-dihydroxyterephthalamides

Org Lett. 2001 Sep 6;3(18):2827-30. doi: 10.1021/ol016253u.

Abstract

[reaction: see text]. 2,3-Dihydroxyterephthalamides have been synthesized through a route that avoids the protection and deprotection of the phenol groups. The procedure allows for symmetric and unsymmetric amide linkages. This synthetic sequence significantly decreases the time and cost of preparation and increases the overall yield of this class of metal chelators.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Chelating Agents / chemical synthesis*
  • Chelating Agents / chemistry
  • Phenol / chemistry
  • Phthalic Acids / chemical synthesis*
  • Phthalic Acids / chemistry

Substances

  • 2,3-dihydroxyterephthalamide
  • Amides
  • Chelating Agents
  • Phthalic Acids
  • Phenol