Abstract
During a 4-month period we prospectively investigated the frequency of polyclonal catheter infections with Staphylococcus epidermidis. Of each catheter with pure growth of S. epidermidis, six colonies were genotypically analyzed with pulsed-field gel electrophoresis. Two out of 12 patients with catheter infection had a polyclonal infection. Both clones of each catheter had a clearly different antibiotic susceptibility. This study shows that polyclonal catheter infections are not exceptional. Further studies are needed to define the clinical consequences of polyclonal catheter infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Bacteremia / drug therapy
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Bacteremia / epidemiology
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Bacteremia / etiology
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Bacteremia / microbiology
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Catheterization, Central Venous / adverse effects*
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Catheters, Indwelling / microbiology
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Cross Infection
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Electrophoresis, Gel, Pulsed-Field
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Equipment Contamination
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Genotype
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Humans
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Infant, Newborn
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Microbial Sensitivity Tests
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Prevalence
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Prospective Studies
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / epidemiology*
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Staphylococcal Infections / etiology
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Staphylococcal Infections / microbiology
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Staphylococcus epidermidis / drug effects
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Staphylococcus epidermidis / genetics
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Staphylococcus epidermidis / isolation & purification*
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Vancomycin / pharmacology
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Vancomycin