Abstract
The recent application of new techniques, such as multi-color cell sorting and the production of transgenic and gene-knockout mice, has contributed to a better understanding of lymphocyte development from hematopoietic stem cells. Now that we can purify progenitors at different maturational stages during lymphocyte development, the challenge is to understand the processes that govern each developmental stage transition.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Differentiation*
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Cell Lineage
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Dendritic Cells / cytology
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Gene Rearrangement / genetics
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / metabolism
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Humans
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Killer Cells, Natural / cytology
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Lymphocytes / cytology*
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Lymphocytes / metabolism*
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Receptors, Antigen / genetics
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Receptors, Cytokine / metabolism
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Signal Transduction
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Transcription Factors / metabolism
Substances
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Receptors, Antigen
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Receptors, Cytokine
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Transcription Factors