Abstract
Substituted isoquinolin-1-ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-N-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Indicators and Reagents
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Isoquinolines / chemical synthesis*
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Isoquinolines / pharmacology*
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Magnetic Resonance Spectroscopy
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Indicators and Reagents
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Isoquinolines