Computer simulation studies using our newly developed mathematical model of human cardiovascular (CV) system were performed to investigate the effect of bladder coverage and inflation schedule of anti-G suit on G protection and CV response. The simulation results agree well with centrifuge experiments. The study demonstrates that additional +Gz protection provided by the extension of the bladder coverage depends mainly upon the pressure transmission efficiency to the underlying tissues and vessels. Although G tolerance increases clearly with the increase of suit inflation schedule, the tendency of increase seems slower when inflation schedule becomes higher than 10 kPa/G.