Abstract
Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Anoikis*
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Carrier Proteins / metabolism
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Cytoskeleton / physiology
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Fas-Associated Death Domain Protein
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Growth Substances / physiology
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Humans
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Integrins / physiology*
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MAP Kinase Signaling System
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Models, Biological
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Neoplasms / pathology
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Phosphatidylinositol 3-Kinases / physiology
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Protein Serine-Threonine Kinases*
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Proto-Oncogene Proteins / physiology
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Proto-Oncogene Proteins c-akt
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Signal Transduction
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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FADD protein, human
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Fas-Associated Death Domain Protein
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Growth Substances
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Integrins
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Proto-Oncogene Proteins
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt