Sequence analysis of the nucleocapsid and phosphoprotein genes of avian pneumoviruses circulating in the US

Virus Res. 2001 Nov 5;79(1-2):15-25. doi: 10.1016/s0168-1702(01)00276-3.

Abstract

Avian pneumovirus (APV) has recently been described as the cause of a new respiratory syndrome in turkey flocks in the United States. We here describe the complete sequence of the nucleocapsid (N) and phosphoprotein (P) genes of this emerging APV (APV/US). Our results show 59 and 61% nucleotide sequence identity of the APV/US N gene with N genes of previously described European APV subgroups A and B, respectively. The P gene of APV/US showed only 53% nucleotide sequence identity with the ortholog from APV subgroup A. Phylogenetic analyses of both N and P genes clearly demonstrate that the APV/US lineage is evolutionarily related but distinct from European APVs. Moreover, sequence analysis of the N and P genes from two laboratory adapted isolates of APV/US (APV/MN-1a and APV/MN-1b) and from ten clinical samples from APV-infected turkeys suggests only modest level of amino acid divergence in the N (0-0.3%) and P (0-1.4%) proteins. Taken together, the results of this study indicate support that APV/US represents a new subgroup (subgroup C) of APV and show that there is limited heterogeneity in the N and P genes of APV/US isolates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bird Diseases / virology
  • Humans
  • Molecular Sequence Data
  • Nucleocapsid / genetics*
  • Phosphoproteins / genetics*
  • Phylogeny
  • Pneumovirus / classification
  • Pneumovirus / genetics*
  • Pneumovirus Infections / veterinary
  • Pneumovirus Infections / virology
  • Sequence Analysis, DNA
  • Turkeys / virology
  • United States
  • Viral Proteins / genetics*

Substances

  • Phosphoproteins
  • Viral Proteins

Associated data

  • GENBANK/AF176590
  • GENBANK/AF176591