Streptococcus pneumoniae isolates with reduced susceptibility to ciprofloxacin in Spain: clonal diversity and appearance of ciprofloxacin-resistant epidemic clones

L Alou; M Ramirez; C García-Rey; J Prieto; H de Lencastre

doi:10.1128/AAC.45.10.2955-2957.2001

Streptococcus pneumoniae isolates with reduced susceptibility to ciprofloxacin in Spain: clonal diversity and appearance of ciprofloxacin-resistant epidemic clones

Antimicrob Agents Chemother. 2001 Oct;45(10):2955-7. doi: 10.1128/AAC.45.10.2955-2957.2001.

Authors

L Alou¹, M Ramirez, C García-Rey, J Prieto, H de Lencastre

Affiliation

¹ Molecular Genetics Laboratory, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, R. da Qta. Grande 6, Oeiras, Portugal.

Abstract

Analysis of the pulsed-field gel electrophoretic profiles of 82 pneumococcal isolates with reduced susceptibility to ciprofloxacin (RSC) and of 90 co-occurring susceptible isolates indicates a considerable genetic diversity among isolates with RCS and points to a close relation between the two groups. This finding suggests that pneumococci with RCS emerge through independent mutational events.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacology*
Ciprofloxacin / pharmacology*
DNA, Bacterial / analysis
Drug Resistance, Microbial / genetics
Electrophoresis, Gel, Pulsed-Field
Genetic Variation
Genotype
Humans
Microbial Sensitivity Tests
Pneumococcal Infections / epidemiology
Pneumococcal Infections / microbiology
Spain / epidemiology
Streptococcus pneumoniae / drug effects*
Streptococcus pneumoniae / genetics

Substances

Anti-Infective Agents
DNA, Bacterial
Ciprofloxacin