[Generalized pustulous psoriasis: A novel extraintestinal manifestation of Crohn's disease?]

Z Gastroenterol. 2001 Sep;39(9):801-5. doi: 10.1055/s-2001-17191.
[Article in German]

Abstract

A 66-year-old female patient suffering for 10 years from Crohn's disease firstly presented with a parallel outbreak of generalized pustulous psoriasis and Crohn's disease. A second synchronous exacerbation of both disorders occurred after discontinuation of treatment with prednisolone, methotrexate, and mesalazine. As to their pathogenetic concepts, both disease entities reveal similar immunologic alterations, i. e. comparable patterns of cytokines, chemokines, and inflammatory cells (T cells and neutrophils). Generalized pustulous psoriasis, therefore, might develop as hitherto undescribed, more rare extraintestinal manifestation of Crohn's disease.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Chemokines / blood
  • Crohn Disease / diagnosis*
  • Crohn Disease / immunology
  • Cytokines / blood
  • Female
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use
  • Leukocyte Count
  • Neutrophils / immunology
  • Psoriasis / diagnosis*
  • Psoriasis / immunology
  • Substance Withdrawal Syndrome / diagnosis
  • Substance Withdrawal Syndrome / immunology
  • T-Lymphocytes / immunology

Substances

  • Chemokines
  • Cytokines
  • Immunosuppressive Agents