Improvements in circulating cholesterol, antioxidants, and homocysteine after dietary intervention in an Australian Aboriginal community

Am J Clin Nutr. 2001 Oct;74(4):442-8. doi: 10.1093/ajcn/74.4.442.

Abstract

Background: Poor nutrition contributes to high rates of coronary heart disease among Australian Aboriginal populations. Since late 1993, the Aboriginal community described here has operated a healthy lifestyle program aimed at reducing the risk of chronic disease.

Objective: We evaluated the effectiveness of a community-directed intervention program to reduce coronary heart disease risk through dietary modification.

Design: Intervention processes included store management policy changes, health promotion activities, and nutrition education aimed at high-risk individuals. Dietary advice was focused on decreasing saturated fat and sugar intake and increasing fruit and vegetable intake. Evaluation of the program included conducting sequential, cross-sectional risk factor surveys at 2-y intervals; measuring fasting cholesterol, lipid-soluble antioxidants, and homocysteine concentrations; and assessing smoking status. Nutrient intakes were estimated from analysis of food turnover in the single community store.

Results: There was a significant reduction in the prevalence of hypercholesterolemia (age-adjusted prevalences were 31%, 21%, and 15% at baseline, 2 y, and 4 y, respectively; P < 0.001). There were significant increases in plasma concentrations of alpha-tocopherol, lutein and zeaxanthin, cryptoxanthin, and beta-carotene across the population. Retinol and lycopene concentrations did not change significantly. Mean plasma homocysteine concentrations decreased by 3 micromol/L. There was no significant change in smoking prevalence between the 2 follow-up surveys. There was an increase in the density of fresh fruit and vegetables and carotenoids in the food supply at the community store.

Conclusion: This community-directed dietary intervention program reduced the prevalence of coronary heart disease risk factors related to diet.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Analysis of Variance
  • Antioxidants / metabolism*
  • Australia
  • Cholesterol / blood*
  • Community Health Services*
  • Coronary Disease / etiology
  • Coronary Disease / prevention & control*
  • Diet*
  • Female
  • Homocysteine / blood*
  • Humans
  • Life Style
  • Male
  • Risk Factors
  • Sex Distribution

Substances

  • Antioxidants
  • Homocysteine
  • Cholesterol