Malignancies arising in oncocytic schneiderian papillomas: a report of 2 cases and review of the literature

Arch Pathol Lab Med. 2001 Oct;125(10):1365-7. doi: 10.5858/2001-125-1365-MAIOSP.

Abstract

Oncocytic schneiderian papillomas (OSPs) are uncommon benign neoplasms that arise from the sinonasal schneiderian epithelium. Malignancies arising in OSPs are rare, and, to our knowledge, only 14 such instances have been reported in the medical literature. We report 2 additional cases--a small cell carcinoma and a sinonasal undifferentiated carcinoma arising in OSPs and presenting synchronously with the benign neoplasm. The potential for malignant transformation in OSPs is small, but warrants that these papillomas be completely excised to exclude a coexisting carcinoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Biomarkers
  • Biopsy
  • Carcinoma / pathology
  • Humans
  • Immunohistochemistry
  • Keratins / analysis
  • Male
  • Middle Aged
  • Nasal Mucosa / pathology*
  • Nose Neoplasms / pathology*
  • Nose Neoplasms / surgery
  • Papilloma / pathology*
  • Papilloma / surgery
  • Paranasal Sinuses / pathology*

Substances

  • Biomarkers
  • CAM 5.2 antigen
  • Keratins