Intensive lowering of serum cholesterol in patients with ischaemic heart disease may retard atherosclerotic progression, and may even cause a limited regression in some patients and partly restore endothelial function. Coronary angiography has been the standard method to evaluate coronary anatomy. However, coronary angiography delineates only the vessel lumen as a silhouette, a perspective that is incapable of reflecting the irregular nature of the atherosclerotic vessel wall changes. Three-dimensional intravascular ultrasound provides cross-sectional and longitudinal images of both the vessel lumen and wall and the plaque volume can be measured in entire arterial segments. Three-dimensional intravascular ultrasound is a reliable technique to measure progression and regression of atherosclerosis in coronary arteries.