Abstract
After 16alpha-[15F]fluoroestradiol ([18F]FES) has been successfully prepared in an automated module, the synthesis of 16alpha-[18F]fluoroestradiol-3,17beta-disulphamate ([18F]FESDS) is described as a module-assisted one-pot procedure which can provide 10GBq [18F]FESDS with a radiochemical purity better than 99%. The procedure is reliable and reproducible and requires a time of about 90 min. Because of its high sulphatase-inhibitory effect [15F]FESDS is thought to be a new PET tracer to image sites of high sulphatase activity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Arylsulfatases / antagonists & inhibitors
-
Enzyme Inhibitors / chemical synthesis
-
Estradiol / analogs & derivatives
-
Estradiol / chemical synthesis*
-
Fluorine Radioisotopes
-
Humans
-
Radiochemistry / instrumentation
-
Radiochemistry / methods
-
Radiopharmaceuticals / chemical synthesis*
-
Steryl-Sulfatase
-
Tomography, Emission-Computed
Substances
-
16-fluoroestradiol-3,17-disulfamate
-
Enzyme Inhibitors
-
Fluorine Radioisotopes
-
Radiopharmaceuticals
-
Estradiol
-
Arylsulfatases
-
Steryl-Sulfatase