Enzymatic characterization of TEM-63, a TEM-type extended spectrum beta-lactamase expressed in three different genera of Enterobacteriaceae from South Africa

Diagn Microbiol Infect Dis. 2001 Aug;40(4):199-201. doi: 10.1016/s0732-8893(01)00266-8.

Abstract

The extended-spectrum beta-lactamase, TEM-63, was identified in three separate genera of South African isolates: Proteus mirabilis, Klebsiella pneumoniae, and Escherichia coli. This paper describes identification of the gene in these isolates and compares relative rates of hyrolysis between TEM-63 and other known ceftazidimases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Substitution
  • Cloning, Molecular
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / genetics*
  • Klebsiella pneumoniae / enzymology*
  • Proteus mirabilis / enzymology*
  • South Africa
  • beta-Lactamases / biosynthesis
  • beta-Lactamases / chemistry
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • beta-lactamase TEM-63
  • beta-Lactamases