Abstract
Genotypic resistance to antiretroviral drugs was examined in 684 individuals attending 18 outpatient clinics distributed across Spain in June 2000. Compared with similar surveys conducted before 1998, the prevalence of resistance to nucleosides has declined significantly among naive chronic HIV carriers. In contrast, resistance among pre-treated patients has increased; resistance to all three drug families having been recognized in nearly a quarter of patients.
MeSH terms
-
Anti-HIV Agents / pharmacology*
-
Anti-HIV Agents / therapeutic use
-
Drug Resistance, Multiple, Viral / genetics
-
Drug Resistance, Viral / genetics*
-
Genotype
-
HIV Infections / drug therapy
-
HIV Infections / epidemiology
-
HIV Infections / virology*
-
HIV Protease / genetics
-
HIV Protease Inhibitors / pharmacology*
-
HIV Protease Inhibitors / therapeutic use
-
HIV Reverse Transcriptase / genetics
-
HIV-1 / drug effects*
-
HIV-1 / enzymology
-
HIV-1 / genetics
-
Humans
-
Mutation
-
Reverse Transcriptase Inhibitors / pharmacology*
-
Reverse Transcriptase Inhibitors / therapeutic use
-
Spain / epidemiology
Substances
-
Anti-HIV Agents
-
HIV Protease Inhibitors
-
Reverse Transcriptase Inhibitors
-
HIV Reverse Transcriptase
-
HIV Protease