Human immunodeficiency virus-positive patients with posterior intracorneal precipitates

Ophthalmology. 2001 Oct;108(10):1853-7. doi: 10.1016/s0161-6420(01)00711-4.

Abstract

Purpose: To describe an unusual and possibly new keratopathy in human immunodeficiency virus (HIV)-positive patients.

Design: Retrospective observational case series.

Participants: : Six HIV-positive patients at four centers.

Methods: A complete medical history was obtained and a thorough ophthalmic examination was performed on each of the patients.

Results: Each patient had bilaterally symmetrical keratopathy consisting of variably pigmented round and reticular posterior intracorneal precipitates at the level of Descemet's membrane. The precipitates were diffuse, but larger and more prominent near the limbus and finer toward the central cornea. None of the eyes were inflamed, and all had normal vision. No patient had uveitis on presentation or any history of cytomegalovirus retinitis.

Conclusion: These patients have a unique posterior keratopathy, which requires further investigation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiviral Agents / therapeutic use
  • Corneal Diseases / diagnosis
  • Corneal Diseases / etiology*
  • Descemet Membrane / pathology*
  • Eye Infections, Viral / diagnosis
  • Eye Infections, Viral / etiology*
  • HIV Seropositivity / complications*
  • HIV Seropositivity / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Visual Acuity

Substances

  • Antiviral Agents