Abstract
Recent advances in the understanding of the genetic basis of Alzheimer's disease have enabled the production of transgenic mouse models of the disease. Utilizing both cDNA- and genomic-based approaches, these mouse models for Alzheimer's disease have already provided valuable insights into the pathogenesis of the disease and potential therapeutic interventions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Alzheimer Disease / etiology
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Alzheimer Disease / genetics*
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Alzheimer Disease / therapy
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Amyloid beta-Protein Precursor / genetics
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Animals
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DNA, Complementary / genetics
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Disease Models, Animal
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Genomics
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Humans
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Mice
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Mice, Transgenic
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Mutation
Substances
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Amyloid beta-Protein Precursor
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DNA, Complementary