Abstract
FISH identified a cryptic t(5;14)(q35;q32) in T acute lymphoblastic leukemia (ALL), whereas it was not observed in B ALL samples. This translocation is present in five out of 23 (22%) children and adolescents with T ALL tested. RanBP17, a gene coding for a member of the importin beta protein family, and Hox11Like2, an orphan homeobox gene were mapped close to the chromosome 5 breakpoints and CTIP2, which is highly expressed during normal T cell differentiation, was localized in the vicinity of the chromosome 14 breakpoints. The Hox11L2 gene was found to be transcriptionally activated as a result of the translocation, probably under the influence of CTIP2 transcriptional regulation elements. These data establish the t(5;14)(q35;q32) as a major abnormality, and Hox11 family member activation as an important pathway in T ALL leukemogenesis.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Amino Acid Sequence
-
Case-Control Studies
-
Cell Transformation, Neoplastic
-
Child
-
Child, Preschool
-
Chromosome Breakage
-
Chromosomes, Human, Pair 14*
-
Chromosomes, Human, Pair 5*
-
Cytogenetic Analysis
-
Female
-
Homeodomain Proteins / genetics*
-
Humans
-
Leukemia-Lymphoma, Adult T-Cell / etiology
-
Leukemia-Lymphoma, Adult T-Cell / genetics*
-
Male
-
Molecular Sequence Data
-
Oncogene Proteins / genetics*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
-
Proto-Oncogene Proteins
-
Sequence Alignment
-
Translocation, Genetic / genetics*
-
ran GTP-Binding Protein / genetics
Substances
-
Homeodomain Proteins
-
Oncogene Proteins
-
Proto-Oncogene Proteins
-
RanGTP-binding protein 17
-
TLX3 protein, human
-
TLX1 protein, human
-
ran GTP-Binding Protein