Abstract
A new series of potent and selective cyclooxygenase-2 inhibitors have been prepared. Some of these compounds show good oral anti-inflammatory activity in rats.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents / therapeutic use
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / chemical synthesis
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Cyclooxygenase Inhibitors / chemistry
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Cyclooxygenase Inhibitors / pharmacology*
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Cyclooxygenase Inhibitors / therapeutic use
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Disease Models, Animal
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Inflammation / drug therapy
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Isoenzymes / antagonists & inhibitors*
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Isoenzymes / metabolism
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Naphthalenes / chemical synthesis
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Naphthalenes / chemistry
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Naphthalenes / pharmacology*
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Naphthalenes / therapeutic use
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Prostaglandin-Endoperoxide Synthases / metabolism
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Rats
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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Naphthalenes
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases