Abstract
Investigations of the structure-activity relationships of 1,3,4-trisubstituted pyrrolidine human CCR5 receptor antagonists afforded orally bioavailable compounds with the ability to inhibit HIV replication in vitro.
MeSH terms
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Administration, Oral
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Animals
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacokinetics
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Anti-HIV Agents / pharmacology*
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Biological Availability
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CCR5 Receptor Antagonists*
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CHO Cells
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Cricetinae
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HIV / drug effects*
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HeLa Cells
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Humans
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Microbial Sensitivity Tests
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Pyrrolidines / chemical synthesis
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Pyrrolidines / chemistry
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Pyrrolidines / pharmacokinetics
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Pyrrolidines / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-HIV Agents
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CCR5 Receptor Antagonists
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Pyrrolidines