A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)

Org Lett. 2001 Oct 18;3(21):3277-80. doi: 10.1021/ol0101638.

Abstract

[structure: see text]. A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anthracenes / chemical synthesis
  • Biosensing Techniques*
  • Copper / analysis*
  • Fluorescence
  • Hydrogen-Ion Concentration
  • Metals, Heavy / analysis
  • Oligopeptides / chemistry*
  • Sensitivity and Specificity
  • Spectrometry, Fluorescence

Substances

  • Anthracenes
  • Metals, Heavy
  • Oligopeptides
  • glycyl-histidyl-lysine
  • 9-anthroic acid
  • Copper