Enantioselective synthesis of spiropentanes from hydroxymethylallenes

Org Lett. 2001 Oct 18;3(21):3293-5. doi: 10.1021/ol0165140.

Abstract

[reaction: see text]. Hydroxymethylallenes are efficiently converted to the corresponding spiropentanes in high yields and enantiomeric ratios upon treatment with Zn(CH2I)2 and dioxaborolane ligand 1. The reaction also proceeds with complete diastereocontrol. The application of this methodology to the synthesis of spiropentaneacetic acid is also presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkadienes / chemistry
  • Enzyme Inhibitors / chemical synthesis
  • Fatty Acid Desaturases / antagonists & inhibitors
  • Spiro Compounds / chemical synthesis*

Substances

  • Alkadienes
  • Enzyme Inhibitors
  • Spiro Compounds
  • spiropentaneacetic acid
  • propadiene
  • Fatty Acid Desaturases