Compressive optic neuropathy caused by renal osteodystrophy. Case report

J Neurosurg. 2001 Oct;95(4):704-9. doi: 10.3171/jns.2001.95.4.0704.

Abstract

Compressive optic neuropathy with acute or chronic vision loss has been associated with various skull base tumors, aneurysms, Graves disease, trauma, and, less commonly, fibrous dysplasia and osteopetrosis. The authors present a case of acute visual deterioration in a 25-year-old woman who had massive calvarial hypertrophy with optic canal stenosis secondary to renal osteodystrophy (uremic leontiasis ossea [ULO]: bighead disease). Significant visual field restoration was achieved with high-dose corticosteroids followed by optic nerve decompression. This is the first case report of cranial neuropathy associated with ULO.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chronic Kidney Disease-Mineral and Bone Disorder / complications*
  • Chronic Kidney Disease-Mineral and Bone Disorder / diagnosis
  • Chronic Kidney Disease-Mineral and Bone Disorder / diagnostic imaging
  • Chronic Kidney Disease-Mineral and Bone Disorder / drug therapy
  • Decompression, Surgical
  • Female
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use
  • Humans
  • Magnetic Resonance Imaging
  • Methylprednisolone / therapeutic use
  • Optic Nerve Diseases / etiology*
  • Optic Nerve Diseases / physiopathology
  • Optic Nerve Diseases / surgery
  • Scotoma / etiology
  • Scotoma / physiopathology
  • Skull / diagnostic imaging
  • Skull / pathology*
  • Tomography, X-Ray Computed
  • Visual Fields

Substances

  • Glucocorticoids
  • Methylprednisolone