Potent, low molecular weight thrombin receptor antagonists

S Chackalamannil; D Doller; K Eagen; M Czarniecki; H S Ahn; C J Foster; G Boykow

doi:10.1016/s0960-894x(01)00555-8

Potent, low molecular weight thrombin receptor antagonists

Bioorg Med Chem Lett. 2001 Nov 5;11(21):2851-3. doi: 10.1016/s0960-894x(01)00555-8.

Authors

S Chackalamannil¹, D Doller, K Eagen, M Czarniecki, H S Ahn, C J Foster, G Boykow

Affiliation

¹ Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07033, USA. [email protected]

PMID: 11597414
DOI: 10.1016/s0960-894x(01)00555-8

Abstract

Several benzimidazole derivatives have been identified as potent thrombin receptor (PAR-1) antagonists as represented by compound 1h, which showed an IC(50) of 33 nM.

MeSH terms

Molecular Weight
Receptors, Thrombin / antagonists & inhibitors*
Structure-Activity Relationship

Substances

Receptors, Thrombin