Abstract
Conditions consistent with tolerance or immunoregulation have been observed in experimental Candida albicans vaginal infections. The present study investigated the role of gamma/delta T cells in experimental vaginal candidiasis. Results showed that T-cell receptor delta-chain-knockout mice had significantly less vaginal fungal burden when compared to wild-type mice, suggesting an immunoregulatory role for gamma/delta T cells in Candida vaginitis.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Candidiasis / immunology*
-
Disease Models, Animal
-
Female
-
Hypersensitivity, Delayed / immunology
-
Mice
-
Mice, Inbred C57BL
-
Mice, Knockout
-
Nitrogen Oxides / metabolism
-
Receptors, Antigen, T-Cell, gamma-delta / genetics
-
Receptors, Antigen, T-Cell, gamma-delta / immunology*
-
T-Lymphocytes / immunology*
-
Th1 Cells / immunology
-
Th2 Cells / immunology
-
Vaginitis / immunology*
Substances
-
Nitrogen Oxides
-
Receptors, Antigen, T-Cell, gamma-delta