Objective: To investigate the effects of antisense 6A8 cDNA on the malignant behavior of tumor.
Methods: Highly metastatic clonal variant CNE-2L2 from nasopharygeal carcinoma cell line(CNE-2Z) was transfected with antisense 6A8 cDNA or mock plasmid. Their adhesion, locomotion, proteolytic ability, in vitro invasion, in vivo growth and metastasis were comparatively studied with the wild CNE-2L2 cells.
Results: Antisense 6A8 cDNA transfected CNE-2L2 showed less adhesion to FN and LN, weakened locomotive ability and proteolytic ability, retarded in vivo growth and much less metastasis.
Conclusion: Transfection of antisense 6A8 cDNA obviously decreased the malignant behavior of tumor cells.