Abstract
Studies on the chemical constituents of Phyllanthus urinaria and its antiviral activity against hepatitis B virus were completed. Eleven compounds have been isolated. Two of them are new compounds methyl ester dehydrochebulic acid and methyl brevifolin carboxylate. Antiviral experiments on HBsAg in vitro and liver damage caused by CCl4 have shown that. Phyllanthus urinaria possesses antiviral activities against HBV.
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology
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Carbon Tetrachloride Poisoning
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Chemical and Drug Induced Liver Injury / drug therapy
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Chemical and Drug Induced Liver Injury / etiology
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Drugs, Chinese Herbal / pharmacology*
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Euphorbiaceae / chemistry*
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Hepatitis B / drug therapy
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Hepatitis B virus / drug effects*
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Humans
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Maleates / isolation & purification
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Maleates / pharmacology
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Plants, Medicinal / chemistry*
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Rats
Substances
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Antiviral Agents
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Benzopyrans
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Drugs, Chinese Herbal
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Maleates
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methyl brevifolincarboxylate
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dehydrochebulic acid trimethyl ester