Fatal graft-versus-host disease following HLA-mismatched donor lymphocyte infusion

P J Amrolia; K Rao; O Slater; A Ramsay; P A Veys; D K Webb

doi:10.1038/sj.bmt.1703195

Fatal graft-versus-host disease following HLA-mismatched donor lymphocyte infusion

Bone Marrow Transplant. 2001 Sep;28(6):623-5. doi: 10.1038/sj.bmt.1703195.

Authors

P J Amrolia¹, K Rao, O Slater, A Ramsay, P A Veys, D K Webb

Affiliation

¹ Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK.

PMID: 11607779
DOI: 10.1038/sj.bmt.1703195

Abstract

We report the case of a 10-year-old boy with molecular relapse of CML following unrelated donor BMT who developed fatal grade 4 acute GVHD of the gut and liver following one antigen-mismatched donor lymphocyte infusion. Previous experience of donor lymphocyte infusion in the HLA-mismatched setting is reviewed and the role of adoptive immunotherapy in this situation is discussed.

Publication types

Case Reports

MeSH terms

Bone Marrow Transplantation / adverse effects
Bone Marrow Transplantation / immunology
Child
Fatal Outcome
Graft vs Host Disease / etiology*
Histocompatibility
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
Lymphocyte Transfusion / adverse effects*
Male
Transplantation, Homologous / adverse effects
Transplantation, Homologous / immunology