Abstract
Investigation of the lipophilic extract of the Red Sea sponge Diacarnus erythraenus revealed one new norsesterterpene cyclic peroxide, aikupikoxide A (1), three new norditerpene cyclic peroxides, aikupikoxide B-D (2-4), and the known norterpene peroxides muqubilin and nuapapuin A methyl ester. In addition, a new sesquiterpene, O-methyl guaianediol, was isolated. Their structures were determined by means of spectroscopic methods. The cytotoxic activities for the isolated compounds have been reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Chromatography, High Pressure Liquid
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Colonic Neoplasms
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Drug Screening Assays, Antitumor
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Egypt
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Humans
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Indian Ocean
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Inhibitory Concentration 50
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Leukemia P388
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Lung Neoplasms
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Peroxides / chemistry
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Peroxides / isolation & purification*
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Peroxides / pharmacology
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Porifera / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Stereoisomerism
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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O-methylguaianediol
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Peroxides
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Sesquiterpenes
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Terpenes
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aikupikoxide A
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aikupikoxide B
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aikupikoxide C
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aikupikoxide D