Abstract
[structure: see text]. A new alkyl-substituted nonenolide, microcarpalide 1, has been isolated from fermentation broths of an unidentified endophytic fungus. Microcarpalide is weakly cytotoxic to mammalian cells and acts as a microfilament disrupting agent. The structure of 1 was elucidated by application of spectroscopic methods. The absolute configuration was determined by the exciton chirality method.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Actin Cytoskeleton / drug effects*
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Alkenes / chemical synthesis*
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Cell Line
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Circular Dichroism
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Fungi / chemistry*
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Humans
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Lactones / chemical synthesis*
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Magnetic Resonance Spectroscopy
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Microscopy, Fluorescence
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Molecular Conformation
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Muscle, Smooth / cytology
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Muscle, Smooth / drug effects
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Rats
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Stereoisomerism
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Tumor Cells, Cultured
Substances
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Alkenes
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Antineoplastic Agents
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Lactones
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oximidine I
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oximidine II