A selectively deprotectable triazacyclophane scaffold for the construction of artificial receptors

Org Lett. 2001 Nov 1;3(22):3499-502. doi: 10.1021/ol0101741.

Abstract

[reaction: see text]. The synthesis of a triazacylclophane scaffold bearing a set of selectively removable protecting groups is described. This versatile scaffold, which can be linked to a solid support, allows the attachment of three different side chains and can therefore be used for the combinatorial synthesis of libraries of artificial receptor molecules of high structural diversity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Aza Compounds / chemical synthesis*
  • Aza Compounds / chemistry
  • Chromatography, High Pressure Liquid
  • Crystallization
  • Dipeptides / chemistry
  • Glycopeptides / chemistry*
  • Indicators and Reagents
  • Ligands
  • Molecular Mimicry
  • Receptors, Peptide / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Ultraviolet

Substances

  • Anti-Bacterial Agents
  • Aza Compounds
  • Dipeptides
  • Glycopeptides
  • Indicators and Reagents
  • Ligands
  • Receptors, Peptide
  • alanylalanine