Abstract
[reaction: see text]. A total synthesis of racemic lepadiformine has been achieved via a route that utilizes as key steps a novel stereocontrolled intramolecular spirocyclization of an allylsilane/N-acyliminium ion and the application of our radical-based methodology for production of N-acylimines from o-aminobenzamides.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaloids / chemical synthesis*
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Animals
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Cardiovascular Agents / chemical synthesis*
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Crystallography, X-Ray
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Cyclization
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Indicators and Reagents
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Urochordata / chemistry*
Substances
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Alkaloids
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Cardiovascular Agents
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Indicators and Reagents
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lepadiformine