Abstract
Myostatin, a member of the TGF beta superfamily, regulates skeletal muscle size by controlling embryonic myoblast proliferation. Recent results show that myostatin may also have a role in muscle regeneration and muscle wasting of adult animals. This review summarizes the recent developments in the regulation of myostatin gene expression and mechanism of its function.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Gene Expression
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Homeostasis / physiology
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Humans
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Muscle, Skeletal / embryology
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Muscle, Skeletal / physiology*
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Myostatin
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Regeneration / physiology*
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Transcription, Genetic
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Transforming Growth Factor beta / genetics
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Transforming Growth Factor beta / physiology*
Substances
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MSTN protein, human
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Myostatin
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Transforming Growth Factor beta