[Expression and significance of vascular permeability factor in nasal polyps]

Zhonghua Er Bi Yan Hou Ke Za Zhi. 1998 Oct;33(5):297-8.
[Article in Chinese]

Abstract

Objective: To study the expression and significance of vascular permeability factor(VPF) in nasal polyps.

Methods: Expression of VPF and its receptor flk-1 in nasal polyps from 9 patients and inferior turbinates from 8 patients with chronic rhinitis were prospectively studied with immunohistochemistry. Each tissue section was observed under optical microscope.

Results: The VPF positivity in vascular endothelium and in gland cell was significantly higher in nasal polyps than in inferior turbinates (P < 0.01 and P < 0.05, respectively). The flk-1 labeling index of vascular endothelium was significantly higher in nasal polyps than that in inferior turbinates (P < 0.01).

Conclusion: VPF may play a key role in the formation of heavy edema of nasal polyps.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Endothelial Growth Factors / analysis*
  • Endothelium, Vascular / chemistry
  • Female
  • Humans
  • Lymphokines / analysis*
  • Male
  • Middle Aged
  • Nasal Polyps / metabolism*
  • Prospective Studies
  • Receptor Protein-Tyrosine Kinases / analysis
  • Receptors, Growth Factor / analysis
  • Receptors, Vascular Endothelial Growth Factor
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Lymphokines
  • Receptors, Growth Factor
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Vascular Endothelial Growth Factor