Abstract
Two new labdane-class diterpenes, cacofurans A (1) and B (2), have been isolated from a sponge Cacospongia sp. Their structures were determined by analyzing spectroscopic data, by chemical transformations, and by X-ray diffraction. Cacofurans 1 and 2 inhibited the development of fertilized sea urchin eggs at concentrations of 0.5 and 5 microg/mL and showed an actin-disrupting effect on the NBT-II cell line at 10 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromatography, High Pressure Liquid
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Convolvulaceae / chemistry*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Dose-Response Relationship, Drug
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Japan
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Leukemia, Lymphoid
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Male
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Mice
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Molecular Conformation
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Molecular Structure
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Porifera / chemistry*
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Rats
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Sea Urchins / drug effects
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Sea Urchins / embryology
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Spermatozoa / drug effects
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Stereoisomerism
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Tumor Cells, Cultured / drug effects
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Urinary Bladder Neoplasms
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X-Ray Diffraction
Substances
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Diterpenes
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Furans
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cacofuran A
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cacofuran B