Abstract
Two new steroidal alkaloids, along with a previously reported one of the plakinamine class, were isolated from the sponge Corticium sp. collected from Guam. The structures of the new compounds were determined by combined spectroscopic methods. These compounds exhibited moderate cytotoxicity and antifungal activity as well as DNA- and RNA-cleaving activities.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Candida albicans / drug effects
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Chromatography, High Pressure Liquid
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DNA / drug effects
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DNA, Bacterial / drug effects
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Drug Screening Assays, Antitumor
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Electrophoresis
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Escherichia coli / genetics
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Guam
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Humans
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Leukemia
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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RNA, Ribosomal, 16S / drug effects
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Steroids / chemistry
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Steroids / isolation & purification*
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Steroids / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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Alkaloids
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Antineoplastic Agents
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DNA, Bacterial
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RNA, Ribosomal, 16S
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Steroids
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plakinamine E
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plakinamine F
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lokysterolamine A
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DNA